The MitoCardia network provides an unprecedented opportunity to comprehensively characterize the mechanisms that regulate mitochondrial mediated cell death via opening of the mitochondrial permeability transition pore, the main mechanism of cardiac cell death following myocardial infarction. This network will use these insights to develop new avenues for therapeutic intervention in heart disease.
The unique team structure and pioneering expertise of the partnership allows us to work together with a major common goal to understand the role of mitochondria and specifically their molecular transport systems in regulating cardiomyocyte death with the goal of designing targeted cardioprotective interventions that translate into clinical practice.
The network combines experts in different fields, from chemistry to mitochondrial biology to animal models and human studies. This interaction between basic and clinical investigators will promote the discovery of new basic information and facilitate its translation to clinical medicine. This international network brings together biologic and chemistry-based scientists to address a singular medical need in synthesizing and testing novel drugs for inhibition of the components that induce cell death. Because of the limited pool of chemists and clinicians interested in cardioprotection, overcoming this barrier is best achieved by this global partnership, the teams of which have already made seminal contributions to the field including:
Demonstration that genetic ablation of one the key proteins that is influenced by the dysregulation of the mitochondria can be cardioprotective, and identified another protein which plays a key role in critical collapse.
Screening of over 360,000 existing therapeutic compounds, performing structure-activity studies and using this info to synthesise totally novel and innovative future therapeutic possibilities.
Generation of new insights into further cell systems and their associated proteins, including their modifications that are potentially involved in the inappropriate cell death
Pioneering the study of the molecular channel that exists between the energy generating component (mitochondria) of the cell and the cell itself, which when made dysfunctional results in the mitochondria shutting down and the cell dying
Implementation of many preliminary and advanced clinical studies for assessing novel therapies as treatments for patients with acute myocardial infarction